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Mutations often occur in the virus and it is possible that some mutations could create a more contagious virus that could cause a regional epidemic or. Many typhus epidemics raged throughout Europe.

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In 1760 the disease was named typhus from the Greek smoke or stupor because of the symptom of delirium that can develop.

. Further descriptions over time termed the disease gaol or jail fever. Human cases of highly pathogenic bird flu have been largely confined to Southeast Asia India Bangladesh and Africa. In 1759 English authorities estimated about 25 of all prisoners in England died of gaol fever per year.

Since that time H5N1 has infected about 860 individuals with about a 50-60 death rate.

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